Serotonergic vulnerability and depression: assumptions, experimental evidence and implications

LAW Jans, WJ Riedel, CR Markus, A Blokland - Molecular psychiatry, 2007 - nature.com
In recent years, the term serotonergic vulnerability (SV) has been used in scientific literature,
but so far it has not been explicitly defined. This review article attempts to elucidate the SV …

Effect of estrogen-serotonin interactions on mood and cognition

Z Amin, T Canli, CN Epperson - Behavioral and cognitive …, 2005 - journals.sagepub.com
Both the neurotransmitter serotonin and the ovarian steroid estrogen have been implicated
in the modulation of mood and cognition. Although significant functional interactions …

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

G Clarke, S Grenham, P Scully, P Fitzgerald… - Molecular …, 2013 - nature.com
Bacterial colonisation of the intestine has a major role in the post-natal development and
maturation of the immune and endocrine systems. These processes are key factors …

Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy

LC Daws - Pharmacology & therapeutics, 2009 - Elsevier
Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and
DAT respectively), are the key players terminating transmission of these amines in the …

Lack of functional estrogen receptor β influences anxiety behavior and serotonin content in female mice

DB Imwalle, JÅ Gustafsson, EF Rissman - Physiology & behavior, 2005 - Elsevier
Estrogen has been linked to the modulation of anxiety in females. Here we report results of
anxiety tests conducted in female estrogen receptor β (ERβ) knockout (ERβKO) and wild …

Sex differences in tryptophan metabolism: A systematic review focused on neuropsychiatric disorders

ML Pais, J Martins, M Castelo-Branco… - International Journal of …, 2023 - mdpi.com
Tryptophan (Tryp) is an essential amino acid and the precursor of several neuroactive
compounds within the central nervous system (CNS). Tryp metabolism, the common …

Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems

V Birzniece, T Bäckström, IM Johansson… - Brain research …, 2006 - Elsevier
This article will review neuroactive steroid effects on serotonin and GABA systems, along
with the subsequent effects on cognitive functions. Neurosteroids (such as estrogen …

Estrogen and serotonin: complexity of interactions and implications for epileptic seizures and epileptogenesis

FH Pottoo, MN Javed, MA Barkat… - Current …, 2019 - ingentaconnect.com
A burgeoning literature documents the confluence of ovarian steroids and central
serotonergic systems in the injunction of epileptic seizures and epileptogenesis. Estrogen …

Ontogeny and regulation of the serotonin transporter: providing insights into human disorders

LC Daws, GG Gould - Pharmacology & therapeutics, 2011 - Elsevier
Abstract Serotonin (5-hydroxytryptamine, 5-HT) was one of the first neurotransmitters for
which a role in development was identified. Pharmacological and gene knockout studies …

Low environmental levels of fluoxetine induce spawning and changes in endogenous estradiol levels in the zebra mussel Dreissena polymorpha

R Lazzara, M Blázquez, C Porte, C Barata - Aquatic toxicology, 2012 - Elsevier
The pharmaceutical fluoxetine, a selective serotonin reuptake inhibitor (SSRI), is often
detected in municipal wastewater treatment plant effluents and surface waters within the ng/l …