The leading parameters that define treatment recommendations in early breast cancer are
oestrogen-receptor, progesterone-receptor, and human epidermal growth-factor status …

Cancer accounts for one in seven deaths worldwide and is the second leading cause of
death in the United States, after heart disease. One of the standard cancer treatments is …

Although immunohistochemical detection of the Ki67 antigen has been used for many years
to assess cancer proliferation, this marker is still not recommended for routine use in clinical …

Breast cancer is a heterogeneous disease comprising the estrogen receptor (ER)–positive
luminal subtype which is subdivided into luminal A and luminal B and ER-negative breast …

Background: Ki67 is an immunohistochemical proliferation marker in many types of cancer
and has been widely studied among breast cancer patients mostly through retrospective …

The key characteristics (KC) of human carcinogens provide a uniform approach to
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …

Molecular profiling is central in cancer precision medicine but remains costly and is based
on tumor average profiles. Morphologic patterns observable in histopathology sections from …

Introduction Although the prognostic significance of proliferation in early invasive breast
cancer has been recognized for a long time, recent gene-expression profiling studies have …

Colorectal cancer (CRC) is one of the most common cancers in the Western world. 5-
Fluorouracil (5FU)-based chemotherapy (CT) remains the mainstay treatment of CRC in the …

Breast cancer is a heterogeneous disease comprising a diversity of tumor subtypes that
manifest themselves in a wide variety of clinical, pathological, and molecular features. One …