The current guideline represents the 6th edition of the “Japanese Clinical Practice Guideline
for Diabetes” which has been revised every three years since its first appearance in 2004 to …

Clinical pancreatic islet transplantation can be considered one of the safest and least
invasive transplant procedures. Remarkable progress has occurred in both the technical …

An open-label, first-in-human phase 1/2 study is being conducted to evaluate the safety and
efficacy of pancreatic endoderm cells (PECs) implanted in non-immunoprotective …

OBJECTIVE Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events
(SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D) …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

Solid organ transplantation (SOT) has emerged from an experimental approach in the 20 th
century to now being an established and practical definitive treatment option for patients with …

The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to
reduce disease complications. For some patients, technological approaches to insulin …

OBJECTIVE To describe trends of primary efficacy and safety outcomes of islet
transplantation in type 1 diabetes recipients with severe hypoglycemia from the …

Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …

Abstract Development of a cell therapy for diabetes would be greatly aided by a renewable
supply of human β-cells. Here we show that pancreatic endoderm derived from human …