Although substantial advances have been made in behavioral and pharmacological
treatments for addictions, moving treatment development to the next stage may require novel …

Serotonin (5-HT) regulates important biological and psychological processes including
mood, and may be associated with the development of several psychiatric disorders. An …

Objective: Severe drinking can cause serious morbidity and death. Because the serotonin
transporter (5-HTT) is an important regulator of neuronal 5-HT function, allelic differences at …

Intra-articular delivery of therapeutics to modulate osteoarthritis (OA) is challenging. Delivery
of interleukin-1 receptor antagonist (IL-1Ra), the natural protein inhibitor of IL-1, to modulate …

Objective The authors previously reported that the 5′-HTTLPR-LL and rs1042173-TT
(SLC6A4-LL/TT) genotypes in the serotonin transporter gene predicted a significant …

Alcohol dependence remains among the most common substance abuse problems
worldwide, and compulsive alcohol consumption is a significant public health concern …

Converging lines of evidence indicate that stress increases risk of addictive behaviors (1).
Early life stress and child maltreatment, chronic cumulative adversity, major life trauma, and …

Alcohol use disorder (AUD) is highly prevalent and among the leading causes of morbidity
and mortality in the United States. Pharmacotherapies for AUD are limited, thus making …

Compared to other medical disorders, including other brain diseases, the number of
medications approved for alcohol use disorder (AUD) is very small. Disulfiram, naltrexone …

Background: The propensity for severe drinking is hypothesized to be regulated by
differential expression of serotonin transporter gene (SLC6A4) in the human brain. The …