Anthracyclines: biosynthesis, engineering and clinical applications
MB Hulst, T Grocholski, JJC Neefjes… - Natural Product …, 2022 - pubs.rsc.org
Covering: January 1995 to June 2021 Anthracyclines are glycosylated microbial natural
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …
Glycosyltransferases: mechanisms and applications in natural product development
DM Liang, JH Liu, H Wu, BB Wang, HJ Zhu… - Chemical Society …, 2015 - pubs.rsc.org
Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …
Natural‐product sugar biosynthesis and enzymatic glycodiversification
CJ Thibodeaux, CE Melançon III… - Angewandte Chemie …, 2008 - Wiley Online Library
Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …
derive their activities from sugar substituents. Changing the structures of these sugars can …
Enzymatic methods for glyco (diversification/randomization) of drugs and small molecules
RW Gantt, P Peltier-Pain, JS Thorson - Natural product reports, 2011 - pubs.rsc.org
Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …
Coculture of marine invertebrate-associated bacteria and interdisciplinary technologies enable biosynthesis and discovery of a new antibiotic, keyicin
N Adnani, MG Chevrette, SN Adibhatla… - ACS chemical …, 2017 - ACS Publications
Advances in genomics and metabolomics have made clear in recent years that microbial
biosynthetic capacities on Earth far exceed previous expectations. This is attributable, in …
biosynthetic capacities on Earth far exceed previous expectations. This is attributable, in …
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
ES Sattely, MA Fischbach, CT Walsh - Natural product reports, 2008 - pubs.rsc.org
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways -
Natural Product Reports (RSC Publishing) DOI:10.1039/B801747F Royal Society of Chemistry …
Natural Product Reports (RSC Publishing) DOI:10.1039/B801747F Royal Society of Chemistry …
Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic …
AR Han, JW Park, MK Lee, YH Ban… - Applied and …, 2011 - Am Soc Microbiol
Doxorubicin, one of the most widely used anticancer drugs, is composed of a tetracyclic
polyketide aglycone and l-daunosamine as a deoxysugar moiety, which acts as an important …
polyketide aglycone and l-daunosamine as a deoxysugar moiety, which acts as an important …
Natural product glycosyltransferases: properties and applications
GJ Williams, JS Thorson - … in Enzymology & Related Areas of …, 2009 - books.google.com
Natural product glycosyltransferases: properties and applications Page 67 NATURAL PRODUCT
GLYCOSYLTRANSFERASES: PROPERTIES AND APPLICATIONS By GAVIN J. WILLIAMS and …
GLYCOSYLTRANSFERASES: PROPERTIES AND APPLICATIONS By GAVIN J. WILLIAMS and …
Dissecting glycosylation steps in lobophorin biosynthesis implies an iterative glycosyltransferase
S Li, J Xiao, Y Zhu, G Zhang, C Yang, H Zhang… - Organic …, 2013 - ACS Publications
The identification of a lobophorin biosynthetic gene cluster from the deep-sea derived
Streptomyces sp. SCSIO 01127 reveals a paradigm of three glycosyltransferases (GTs) …
Streptomyces sp. SCSIO 01127 reveals a paradigm of three glycosyltransferases (GTs) …
[HTML][HTML] New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis
A González, M Rodríguez, AF Braña, C Méndez… - Microbial cell …, 2016 - Springer
Background Streptomyces albus J1074 produces glycosylated antibiotics paulomycin A, B
and E that derive from chorismate and contain an isothiocyanate residue in form of paulic …
and E that derive from chorismate and contain an isothiocyanate residue in form of paulic …