Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Vascular dysfunction is a hallmark of chronic diseases in elderly. The contribution of the
vasculature to lung repair and fibrosis is not fully understood. Here, we performed an …

Components of the chromatin remodelling switch/sucrose nonfermentable (SWI/SNF)
complex are recurrently mutated in tumors, suggesting that altering the activity of the …

Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the
brains of patients with Alzheimer's disease (AD), the pathogenesis of AD is also thought to …

Aging is the universal, intrinsic, genetically-controlled, evolutionarily-conserved and time-
dependent intricate biological process characterised by the cumulative decline in the …

As average life span and elderly people prevalence in the western world population is
gradually increasing, the incidence of age-related diseases such as cancer, heart diseases …

Gene expression is regulated by changes in chromatin architecture intrinsic to cellular
differentiation and as an active response to environmental stimuli. Chromatin dynamics are …