Individual cells and epithelia control the chemical exchange with the surrounding
environment by the fine-tuned expression, localization, and function of an array of …

Neurosensory responses of hearing and balance are mediated by receptors in specialized
neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways …

Genetic hearing loss crosses almost all the categories of hearing loss which includes the
following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital …

The cochlea of the mammalian inner ear contains an endolymph that exhibits an
endocochlear potential (EP) of+ 80 mV with a [K+] of 150 mM. This unusual extracellular …

Introduction Hearing impairment (HI) is characterized by complex genetic heterogeneity. The
evolution of next generation sequencing, including targeted enrichment panels, has …

Abstract The School of Pharmacy and Pharmaceutical Sciences at Trinity College Dublin
hosted the “1 st Workshop on Drug Transporters in the Lungs” in September 2016 to discuss …

Navigating genetic diagnostics in patients with hearing loss : Current Opinion in Pediatrics
Navigating genetic diagnostics in patients with hearing loss : Current Opinion in Pediatrics …

Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help
to decode the sound in order to understand spoken language. Exposure to intense noise …

Variants in the gene NDP cause Norrie disease, a severe dual-sensory disorder
characterized by congenital blindness due to disrupted retinal vascular development and …

Over the past decade, advancements in high-throughput sequencing have greatly enhanced
our knowledge of the mutational signatures responsible for hereditary hearing loss. In its …