Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Genomic data often highlights an inconsistency between the number of gene clusters
identified using bioinformatic approaches as potentially producing secondary metabolites …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a promising
source of new antimicrobials in the face of rising antibiotic resistance. Here, we report a …

Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …

The combination of sequential biocatalytic reactions, via non-natural synthetic cascades, is a
rapidly developing field and leads to the generation of complex valuable chemicals from …

Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …

Microbial secondary metabolites are a potent source of antibiotics and other
pharmaceuticals. Genome mining of their biosynthetic gene clusters has become a key …

Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Bacterial and fungal secondary metabolism is a rich source of novel bioactive compounds
with potential pharmaceutical applications as antibiotics, anti-tumor drugs or cholesterol …