Radiotherapy modulates tumor cell fate decisions: a review

H Chen, Z Han, Q Luo, Y Wang, Q Li, L Zhou, H Zuo - Radiation Oncology, 2022 - Springer
Cancer has always been a worldwide problem, and the application of radiotherapy has
greatly improved the survival rate of cancer patients. Radiotherapy can modulate multiple …

[HTML][HTML] Three-dimensional chromatin organization in brain function and dysfunction

V Dileep, LH Tsai - Current opinion in neurobiology, 2021 - Elsevier
Abstract The three-dimensional (3D) organization of chromatin within the nucleus is now
recognized as a bona fide epigenetic property influencing genome function, replication, and …

An expeditious and facile method of amyloid beta (1–42) purification

MA Haque, IS Park - Plos one, 2024 - journals.plos.org
For the study of amyloid beta (Aβ) associated toxicity which is supposed to be the main
pathological agent in Alzheimer's disease (AD), it is important to secure Aβ peptide with …

[HTML][HTML] Involvement of calcium ions in amyloid-β-induced lamin fragmentation

MS Hossain, VS Ramasamy, IS Park - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
Amyloid-β (Aβ) peptide, the main pathogenic peptide in Alzheimer's disease, has been
shown to induce an increase in cytoplasmic calcium concentration (CCC). In the current …

Targeting Caspases 3/6 and Cathepsins L/B May Decrease Laminopathy-Induced Apoptosis in Alzheimer's Disease

A Rustamzadeh, A Tafakhori, A Ariaei… - Journal of …, 2024 - content.iospress.com
Background: Laminopathy is a pathological manifestation observed in Alzheimer's disease
(AD), leading to neuronal apoptosis. Objective: Our objective was to assess inhibitors of …

Evidence for a Strong Relationship between the Cytotoxicity and Intracellular Location of β-Amyloid

MA Haque, MS Hossain, T Bilkis, MI Islam, IS Park - Life, 2022 - mdpi.com
β-Amyloid (Aβ) is a hallmark peptide of Alzheimer's disease (AD). Herein, we explored the
mechanism underlying the cytotoxicity of this peptide. Double treatment with oligomeric 42 …

Inhibition of caspases 3/6 and cathepsins L/B decreases apoptosis caused by laminopathy in Alzheimer's disease

A Rustamzadeh, A Tafakhori, A Ariaei, M Heydari… - 2023 - researchsquare.com
Background Laminopathy is one of the pathological manifestations of Alzheimer's disease,
leading to neuron apoptosis. We aimed to evaluate the inhibitor enzymes potentially …

Involvement of calcium released from endoplasmic reticulum and TLCK and TPCK sensitive-serine proteases in amyloid beta-induced lamin fragmentation

호세인, 엠디, 셀림 - 2022 - oak.chosun.ac.kr
Alzheimer's disease (AD) is the most usual form of dementia and lifethreatening
neurodegenerative disorder in human that results in dysfunction of memory, thinking ability …

Irreversible modifications of chromatin and the nuclear lamina: A review inside the nuclear origin of Alzheimer's disease

L Gil, G Capdeville, I Rodríguez-Leyva… - Revista mexicana de …, 2021 - scielo.org.mx
Dementia is a public health problem with an extraordinary increase in recent years.
Alzheimer's disease (AD) is the most common cause of dementia. This disease has been …