Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins

AM Almeida, JA Queiroz, F Sousa, Â Sousa - Drug discovery today, 2019 - Elsevier
Highlights•Human papillomavirus (HPV) has a primordial role in the development of cervical
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …

[HTML][HTML] Recent advances in the management of anal cancer

MM Symer, HL Yeo - F1000Research, 2018 - ncbi.nlm.nih.gov
Anal cancer is a rare condition, although its incidence has been increasing over the past
several decades, particularly in women. The majority of anal cancers are squamous cell …

Regulatory considerations on the development of mRNA vaccines

R Naik, K Peden - mRNA Vaccines, 2020 - Springer
Developing traditional viral vaccines for infectious diseases usually takes years, as these
are usually produced either by chemical inactivation of the virus or attenuation of the …

Immunological tolerance of low-risk HPV in recurrent respiratory papillomatosis

R Ivancic, H Iqbal, B Desilva, Q Pan… - Clinical & Experimental …, 2020 - academic.oup.com
Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of
the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 …

Human papillomavirus E5 protein, the undercover culprit of tumorigenesis

N Hemmat, HB Baghi - Infectious agents and cancer, 2018 - Springer
Human papillomavirus (HPV) is the most common viral infection of the reproductive tract
worldwide. It has been well documented that the HPV oncoproteins E6 and E7 play …

Recurrent respiratory papillomatosis: update 2018

CS Derkay, AE Bluher - Current opinion in otolaryngology & head …, 2018 - journals.lww.com
RRP is declining in incidence but remains a challenging disease to treat with great costs to
patients, families, and the healthcare system. As the disease continues to be better …

Calreticulin as an Adjuvant In Vivo to Promote Dendritic Cell Maturation and Enhance Antigen‐Specific T Lymphocyte Responses against Melanoma

Z Gong, M Chen, J Miao, CJ Han… - Journal of …, 2022 - Wiley Online Library
An endoplasmic reticulum resident protein, calreticulin (CRT), participates in many cellular
processes. CRT is a tumor‐associated antigen with an important role in antitumor immunity …

Implementation of routine HPV vaccination in the management of recurrent respiratory papillomatosis

Y Yiu, S Fayson, H Smith… - Annals of Otology …, 2019 - journals.sagepub.com
Objectives: To investigate vaccine compliance and clinical outcomes after implementation of
an initiative to provide the human papillomavirus (HPV) vaccine to all patients with recurrent …

Pharmacotherapy for recurrent respiratory papillomatosis (RRP): a treatment update

AJ Donne, A Kinshuck - Expert Opinion on Pharmacotherapy, 2021 - Taylor & Francis
Introduction: Recurrent respiratory papillomatosis is a rare human papillomavirus (HPV)-
induced condition where warts grow within the airway and especially the larynx to effect …

VITAL phase 2 study: Upfront 5‐fluorouracil, mitomycin‐C, panitumumab and radiotherapy treatment in nonmetastatic squamous cell carcinomas of the anal canal …

J Feliu, R Garcia‐Carbonero, J Capdevila… - Cancer …, 2020 - Wiley Online Library
Aim VITAL, a phase II single‐arm study, aimed to evaluate efficacy and safety of
panitumumab addition to 5‐fluorouracil (5‐FU), mitomycin‐C (MMC) and radiotherapy (RT) …