THE concept of preemptive analgesia to reduce the magnitude and duration of
postoperative pain was paved in 1983 by Woolf, 1 who showed evidence for a central …

Ketamine hydrochloride is a well known general anesthetic and short acting analgesic in
use for almost 3 decades. The role of the NMDA receptor in the processing of nociceptive …

IMPLICATIONS: This meta-analysis assesses the ability of preemptive analgesic
interventions to attenuate postoperative pain scores, decrease supplemental postoperative …

IMPLICATIONS: Narcotics alone are not effective in all postoperative patients for adequate
pain relief. They may also be associated with unacceptable side effects. Thus, there remains …

Background Hip and knee replacement are common operative procedures to improve
mobility and quality of life. Adequate pain relief is essential in the postoperative period to …

We investigated whether intraoperative 'subanesthetic doses' of ketamine have a
postoperative anti-hyperalgesic and an analgesic effect and which is the preferential route of …

Summary The PROSPECT Working Group, a collaboration of anaesthetists and surgeons,
conducts systematic reviews of postoperative pain management for different surgical …

IMPLICATIONS: We evaluated, in a qualitative systematic review, the effect of N-methyl d-
aspartate antagonists on reducing postoperative pain and analgesic consumption beyond …

We prospectively studied 30 healthy female patients undergoing intracavitory brachytherapy
applicator insertion for carcinoma of the cervix under spinal anaesthesia. Patients were …

Rationale: Research over the past decade demonstrating that NMDA receptor antagonists
have the ability to inhibit opiate tolerance, sensitization and physical dependence has led to …