Introduction P-glycoprotein (P-gp) is one of the most studied efflux transporters at the blood-
brain barrier. It plays an important role in brain homeostasis by protecting the brain from a …

P-Glycoprotein (P-gp) is an efflux pump located at the blood–brain barrier (BBB) that
contributes to the protection of the central nervous system by transporting neurotoxic …

[18F] MC225 has been developed as a weak substrate of P-glycoprotein (P-gp) aimed to
measure changes in the P-gp function at the blood–brain barrier with positron emission …

Abstract The Blood-Brain Barrier P-glycoprotein (P-gp) function can be altered in several
neurodegenerative diseases and due to the administration of different drugs which may …

Recent studies indicate that inhibition of the efflux transporter P-glycoprotein (P-gp) at the
blood–brain barrier (BBB) may represent a putative strategy to increase the BBB penetration …

Dysregulation of microtubules is commonly associated with several psychiatric and
neurological disorders, including addiction and Alzheimer's disease. Imaging of …

Background It is well recognized that the molar activity of a radioligand is an important
pharmacokinetic parameter, especially in positron emission tomography (PET) of small …

P-glycoprotein, also known as ABCB1, is an efflux transporter located at endothelial cells of
the blood–brain barrier and plays an important role in protecting the brain parenchyma from …

The choice of a reconstruction algorithm in PET affects the accuracy of quantitative
measurements and image interpretation. This study aimed to evaluate the effects of …

Positron emission tomography (PET) is a medical imaging technique capable of obtaining
insight into different brain functions (physiological processes) by using different radioactive …