Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

The heterogeneity of endothelial cells (ECs) across tissues remains incompletely
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …

Cancer cells secrete small membranous extracellular vesicles (EVs) into their
microenvironment and circulation. Although their potential as cancer biomarkers has been …

Abstract Monocarboxylate transporter (MCT) isoforms 1–4 catalyze the proton‐linked
transport of monocarboxylates such as l‐lactate across the plasma membrane, whereas …

Basigin, also called CD147 or EMMPRIN, is a transmembrane glycoprotein that belongs to
the immunoglobulin superfamily. Basigin has isoforms; the common form (basigin or basigin …

Abstract Since Otto Warburg reported the 'addiction'of cancer cells to fermentative glycolysis,
a metabolic pathway that provides energy and building blocks, thousands of studies have …

Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in
metabolism and must be transported across both the plasma membrane and mitochondrial …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

The monocarboxylate transporter MCT4 mediates lactic acid efflux from most tissues that are
dependent on glycolysis for their ATP production. Here we demonstrate that expression of …