Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Brain is a vital organ of the human body which performs very important functions such as
analysis, processing, coordination, and execution of electrical signals. For this purpose, it …

AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

The importance of neuroglia in maintaining normal brain function under physiological and
pathological conditions has been supported by growing evidence in recent years. The most …

The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid,
and neurofibrillary tangles of Alzheimer disease. In vitro, apolipoprotein E in cerebrospinal …

Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein
metabolism, is localized in the senile plaques, congophilic angiopathy, and neurofibrillary …

Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease and is
associated with poor clinical outcome following traumatic brain injury and other …