Host-directed antiviral therapy
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …
Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists
S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
The emerging roles of NOD-like receptors in antiviral innate immune signaling pathways
C Zheng - International journal of biological macromolecules, 2021 - Elsevier
Viral infection triggers host pattern recognition receptors (PRRs) to recognize pathogen-
associated molecular patterns or danger-associated molecular patterns to initiate antiviral …
associated molecular patterns or danger-associated molecular patterns to initiate antiviral …
Nuclear RPSA senses viral nucleic acids to promote the innate inflammatory response
Y Jiang, S Sun, Y Quan, X Wang, Y You… - Nature …, 2023 - nature.com
Innate sensors initiate the production of type I interferons (IFN-I) and proinflammatory
cytokines to protect host from viral infection. Several innate nuclear sensors that mainly …
cytokines to protect host from viral infection. Several innate nuclear sensors that mainly …
Insights into the Anti‐inflammatory and Antiviral Mechanisms of Resveratrol
X Chen, X Song, X Zhao, Y Zhang… - Mediators of …, 2022 - Wiley Online Library
Resveratrol is a naturally occurring stilbene phytoalexin phenolic compound, which has
been extensively studied on its biological activity. It has been widely accepted that …
been extensively studied on its biological activity. It has been widely accepted that …
The battle between host antiviral innate immunity and immune evasion by cytomegalovirus
S Li, Y Xie, C Yu, C Zheng, Z Xu - Cellular and Molecular Life Sciences, 2024 - Springer
Cytomegalovirus (CMV) has successfully established a long-lasting latent infection in
humans due to its ability to counteract the host antiviral innate immune response. During …
humans due to its ability to counteract the host antiviral innate immune response. During …
An insight into current treatment strategies, their limitations, and ongoing developments in vaccine technologies against herpes simplex infections
D Sharma, S Sharma, N Akojwar, A Dondulkar… - Vaccines, 2023 - mdpi.com
Herpes simplex virus (HSV) infection, the most prevalent viral infection that typically lasts for
a lifetime, is associated with frequent outbreaks of oral and genital lesions. Oral herpes …
a lifetime, is associated with frequent outbreaks of oral and genital lesions. Oral herpes …
Herpesviruses and the type III interferon system
Y Yin, HW Favoreel - Virologica Sinica, 2021 - Springer
Type III interferons (IFNs) represent the most recently discovered group of IFNs. Together
with type I IFNs (eg IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune …
with type I IFNs (eg IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune …
Advancing our understanding of corneal herpes simplex virus-1 immune evasion mechanisms and future therapeutics
E Greenan, S Gallagher, R Khalil, CC Murphy… - Viruses, 2021 - mdpi.com
Herpes stromal keratitis (HSK) is a disease that commonly affects the cornea and external
eye and is caused by Herpes Simplex Virus type 1 (HSV-1). This virus infects approximately …
eye and is caused by Herpes Simplex Virus type 1 (HSV-1). This virus infects approximately …
A comprehensive mechanistic review insight into the effects of micronutrients on toll-like receptors functions
AH Faghfouri, R Zarrin, V Maleki, L Payahoo… - Pharmacological …, 2020 - Elsevier
Highlights•Some micronutrients can regulate TLRs gene expression dependent on dose,
duration and cell type.•NF-κB can be regulated by some micronutrients.•Phosphorylation …
duration and cell type.•NF-κB can be regulated by some micronutrients.•Phosphorylation …