Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Abstract Knowledge of genetic origins of obstructive lung diseases has made inhaled gene
therapy an attractive alternative to the current standards of care that are limited to managing …

Epinephrine produces a β-adrenergic receptor-mediated mechanical hyperalgesia and in
vitro sensitization of nociceptor-like neurons in the rat. Hyperalgesic and nociceptor …

Inflammatory pain, characterized by a decrease in mechanical nociceptive threshold
(hyperalgesia), arises through actions of inflammatory mediators, many of which sensitize …

Several problems limit the application of gene transfer to correct the cystic fibrosis (CF) Cl–
transport defect in airway epithelia. These include inefficient transduction with vectors …

Chronic alcohol consumption produces a painful peripheral neuropathy for which there is no
reliably successful therapy, attributable to, in great part, a lack of understanding of the …

Gene transfer to airway epithelia is the most direct approach for treating the progressive lung
disease associated with cystic fibrosis. However, the transduction efficiency is poor when …

Abstract Prostaglandin E 2 (PGE 2) and epinephrine act directly on nociceptors to produce
mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of …

Gene transfer with recombinant murine leukemia viruses (MuLV) provides the potential to
permanently correct inherited lung diseases, such as cystic fibrosis (CF). Several problems …

We have evaluated the contribution of differences in second messenger signalling to sex
differences in inflammatory pain and its control by sex hormones. In normal male but not …