Genome mining methods to discover bioactive natural products
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
Marine natural products
Covering: 2020 This review covers the literature published in 2020 for marine natural
products (MNPs), with 757 citations (747 for the period January to December 2020) referring …
products (MNPs), with 757 citations (747 for the period January to December 2020) referring …
Enzyme function prediction using contrastive learning
Enzyme function annotation is a fundamental challenge, and numerous computational tools
have been developed. However, most of these tools cannot accurately predict functional …
have been developed. However, most of these tools cannot accurately predict functional …
[2+ 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses
P Yang, Q Jia, S Song, X Huang - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to the end of 2021 [2+ 2]-Type cyclobutane natural products are
biosynthetically derived from intermolecular [2+ 2] cycloaddition or intramolecular [2+ 2] …
biosynthetically derived from intermolecular [2+ 2] cycloaddition or intramolecular [2+ 2] …
Bacterial terpenome
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …
structurally diverse family of natural products. Found in all domains of life, there are over 80 …
Class II terpene cyclases: structures, mechanisms, and engineering
Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …
reactions in nature and are responsible for creating the skeletons of more than 95 000 …
The chemistry and biology of fungal meroterpenoids (2009–2019)
M Jiang, Z Wu, L Liu, S Chen - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
Fungal meroterpenoids are secondary metabolites from mixed terpene-biosynthetic origins.
Their intriguing chemical structural diversification and complexity, potential bioactivities, and …
Their intriguing chemical structural diversification and complexity, potential bioactivities, and …
Gram-scale enantioselective synthesis of (+)-lucidumone
G Huang, C Kouklovsky… - Journal of the American …, 2022 - ACS Publications
The first enantioselective total synthesis of (+)-lucidumone is described through a 13-step
synthetic pathway (longest linear sequence). The key steps involve the formation of a …
synthetic pathway (longest linear sequence). The key steps involve the formation of a …
Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids
XR Peng, SB Unsicker, J Gershenzon… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2018 to 2022 Meroterpenoids found in fungal species of the genus Ganoderma
and known as Ganoderma meroterpenoids (GMs) are substances composed of a 1, 2, 4 …
and known as Ganoderma meroterpenoids (GMs) are substances composed of a 1, 2, 4 …