Genome mining methods to discover bioactive natural products

KD Bauman, KS Butler, BS Moore… - Natural Product …, 2021 - pubs.rsc.org
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Marine natural products

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Natural product …, 2022 - pubs.rsc.org
Covering: 2020 This review covers the literature published in 2020 for marine natural
products (MNPs), with 757 citations (747 for the period January to December 2020) referring …

Enzyme function prediction using contrastive learning

T Yu, H Cui, JC Li, Y Luo, G Jiang, H Zhao - Science, 2023 - science.org
Enzyme function annotation is a fundamental challenge, and numerous computational tools
have been developed. However, most of these tools cannot accurately predict functional …

[2+ 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses

P Yang, Q Jia, S Song, X Huang - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to the end of 2021 [2+ 2]-Type cyclobutane natural products are
biosynthetically derived from intermolecular [2+ 2] cycloaddition or intramolecular [2+ 2] …

Bacterial terpenome

JD Rudolf, TA Alsup, B Xu, Z Li - Natural product reports, 2021 - pubs.rsc.org
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Class II terpene cyclases: structures, mechanisms, and engineering

X Pan, JD Rudolf, LB Dong - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …

The chemistry and biology of fungal meroterpenoids (2009–2019)

M Jiang, Z Wu, L Liu, S Chen - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
Fungal meroterpenoids are secondary metabolites from mixed terpene-biosynthetic origins.
Their intriguing chemical structural diversification and complexity, potential bioactivities, and …

Gram-scale enantioselective synthesis of (+)-lucidumone

G Huang, C Kouklovsky… - Journal of the American …, 2022 - ACS Publications
The first enantioselective total synthesis of (+)-lucidumone is described through a 13-step
synthetic pathway (longest linear sequence). The key steps involve the formation of a …

Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids

XR Peng, SB Unsicker, J Gershenzon… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2018 to 2022 Meroterpenoids found in fungal species of the genus Ganoderma
and known as Ganoderma meroterpenoids (GMs) are substances composed of a 1, 2, 4 …

Chemistry of fungal meroterpenoid cyclases

L Barra, I Abe - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to July 2020 Fungal meroterpenoid cyclases are a recently discovered
emerging family of membrane-integrated, non-canonical terpene cyclases. They catalyze …