APOBEC proteins can deaminate cytosine residues in DNA and RNA. This can lead to
somatic mutations, DNA breaks, RNA modifications, or DNA demethylation in a selective …

LINE-1 (L1) is a class of autonomous mobile genetic elements that form somatic mosaicisms
in various tissues of the organism. The activity of L1 retrotransposons is strictly controlled by …

APOBEC3 cytidine deaminases are largely known for their innate immune protection from
viral infections. Recently, members of the family have been associated with a distinct …

The evolutionary conflict between retroviruses and their vertebrate hosts over millions of
years has led to the emergence of cellular innate immune proteins termed restriction factors …

Human immunodeficiency viruses (HIVs) are retroviruses that replicate effectively in human
CD4+ cells and cause the development of acquired immune deficiency syndrome (AIDS) …

Malignant cells ensure telomere maintenance by the alternative lengthening of telomeres
(ALT) in the absence of telomerase activity (TA). The retrotransposons “long interspersed …

Objective To explore whether APOBEC family members are involved in the response to
inappropriate expression of L1 retroelements in primary Sjögren's syndrome (SS) and …

Several APOBEC3 enzymes restrict HIV-1 by deaminating cytosine to form uracil in single-
stranded proviral (−) DNA. However, HIV-1 Vif counteracts their activity by inducing their …

APOBEC3A (A3A)-catalyzed DNA cytosine deamination is implicated in virus and cancer
mutagenesis, and A3A is a target for small molecule drug discovery. The catalytic glutamic …

Exogenous retroviruses are RNA viruses that require reverse transcription for their
replication. Among these viruses, human immunodeficiency virus (HIV) is infectious to …