Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …

It has been 60 yr since the discovery of reactive oxygen species (ROS) in biology and the
beginning of the scientific community's attempt to understand the impact of the unpaired …

Mitochondria play a major role in apoptosis triggered by many stimuli. They integrate death
signals through Bcl-2 family members and coordinate caspase activation through the …

Necrosis has been defined as a type of cell death that lacks the features of apoptosis and
autophagy, and is usually considered to be uncontrolled. Recent research suggests …

During apoptosis, the mitochondrial network fragments. Using short hairpin RNAs for RNA
interference, we manipulated the expression levels of the proteins hFis1, Drp1, and Opa1 …

Necrosis has long been described as a consequence of physico-chemical stress and thus
accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well …

▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β,
and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF …

Organelle transport is vital for the development and maintenance of axons, in which the
distances between sites of organelle biogenesis, function, and recycling or degradation can …