Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Highlights•Sixteen leading groups review evidence for the therapeutic effects of
agmatine.•Agmatine modulatory action at multiple molecular targets is highlighted.• …

The advance in our understanding of the biogenesis of various endogenous opioid
peptides, their anatomical distribution, and the characteristics of the multiple receptors with …

• Introduction• Metabolism and transport of physiological polyamines• Are physiological
polyamines stress molecules?• Roles of physiological polyamines in oxidative stress …

Chronic pain, especially neuropathic pain and cancer pain, is often not adequately treated
by currently available analgesics. Animal models provide pivotal systems for preclinical …

Agmatine is an endogenous neuromodulator that, based on animal studies, has the
potential for new drug development. As an endogenous aminoguanidine compound (1 …

An early response to an acute inflammatory insult, such as wound healing or experimental
glomerulonephritis, is the conversion of arginine to the cytostatic molecule nitric oxide (NO) …

Nerve growth factor (NGF) has been implicated as an effector of inflammatory pain because
it sensitizes primary afferents to noxious thermal, mechanical, and chemical [eg, capsaicin, a …

Systemic administration of analgesics can lead to serious adverse side effects
compromising therapeutic benefit in some patients. Information coding pain transmits along …

This paper describes a model of tumor-induced bone destruction and hyperalgesia
produced by implantation of fibrosarcoma cells into the mouse calcaneus bone. Histological …