To kill a microglia: a case for CSF1R inhibitors
Microglia, the brain's immune sentinels, have garnered much attention in recent years.
Researchers have begun to identify the manifold roles that these cells play in the central …
Researchers have begun to identify the manifold roles that these cells play in the central …
[HTML][HTML] The M-CSF receptor in osteoclasts and beyond
SH Mun, PSU Park, KH Park-Min - Experimental & molecular medicine, 2020 - nature.com
Colony-stimulating factor 1 receptor (CSF1R, also known as c-FMS) is a receptor tyrosine
kinase. Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R …
kinase. Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R …
[HTML][HTML] Microglia coordinate cellular interactions during spinal cord repair in mice
Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …
[HTML][HTML] Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in …
Neuropsychological deficits, including impairments in learning and memory, occur after
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …
[HTML][HTML] Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges
Microglia are specialized dynamic immune cells in the central nervous system (CNS) that
plays a crucial role in brain homeostasis and in disease states. Persistent …
plays a crucial role in brain homeostasis and in disease states. Persistent …
[HTML][HTML] The role of microglia in modulating neuroinflammation after spinal cord injury
The pathobiology of traumatic and nontraumatic spinal cord injury (SCI), including
degenerative myelopathy, is influenced by neuroinflammation. The neuroinflammatory …
degenerative myelopathy, is influenced by neuroinflammation. The neuroinflammatory …
[HTML][HTML] Depletion of microglia exacerbates injury and impairs function recovery after spinal cord injury in mice
H Fu, Y Zhao, D Hu, S Wang, T Yu, L Zhang - Cell death & disease, 2020 - nature.com
The role of microglia in spinal cord injury (SCI) remains ambiguous, partially due to the
paucity of efficient methods to discriminate these resident microglia with blood-derived …
paucity of efficient methods to discriminate these resident microglia with blood-derived …
[HTML][HTML] Current knowledge of microglia in traumatic spinal cord injury
L Xu, J Wang, Y Ding, L Wang, YJ Zhu - Frontiers in neurology, 2022 - frontiersin.org
Microglia are the resident immune cells in the central nervous system (CNS). After traumatic
spinal cord injury (SCI), microglia undergo activation, proliferation, and changes in gene and …
spinal cord injury (SCI), microglia undergo activation, proliferation, and changes in gene and …
Role of microglia in spinal cord injury
A Kroner, JR Almanza - Neuroscience letters, 2019 - Elsevier
Myeloid cells are important effector cells in the injured spinal cord tissue. Microglia and
monocyte-derived macrophages serve important functions in the injured spinal cord, and …
monocyte-derived macrophages serve important functions in the injured spinal cord, and …
A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation
Microglia/macrophage mediated-inflammation, a main contributor to the microenvironment
after spinal cord injury (SCI), persists for a long period of time and affects SCI repair …
after spinal cord injury (SCI), persists for a long period of time and affects SCI repair …