Transcription-factor-based biosensors (TFBs) are often used for metabolite detection,
adaptive evolution, and metabolic flux control. However, designing TFBs with superior …

The discovery of penicillin entailed a decisive breakthrough in medicine. No other medical
advance has ever had the same impact in the clinical practise. The fungus Penicillium …

Synthetic biology has the potential to bring forth advanced genetic devices for applications
in healthcare and biotechnology. However, accurately predicting the behavior of engineered …

The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …

Here we ask: What is productive signaling? How to define it, how to measure it, and most of
all, what are the parameters that determine it? Further, what determines the strength of …

Ectoine is a high-value protective and stabilizing agent with different applications in
biopharmaceuticals, biotechnology, and fine chemicals. Here, efficient production of ectoine …

Drug resistance continues to impede the success of cancer treatments, creating a need for
experimental model systems that are broad, yet simple, to allow the identification of …

A major pharmacological assumption is that lowering disease-promoting protein levels is
generally beneficial. For example, inhibiting metastasis activator BACH1 is proposed to …

Engineered signaling networks can impart cells with new functionalities useful for directing
differentiation and actuating cellular therapies. For such applications, the engineered …

One of the most remarkable features of biological systems is their ability to adapt to the
constantly changing environment. By harnessing principles of control theory, synthetic …