Epigenetic modifications and human disease
A Portela, M Esteller - Nature biotechnology, 2010 - nature.com
Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …
Epigenetics in cancer
Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …
Cancer epigenetics reaches mainstream oncology
M Rodríguez-Paredes, M Esteller - Nature medicine, 2011 - nature.com
Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …
DNA methylation and cancer
M Kulis, M Esteller - Advances in genetics, 2010 - Elsevier
DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …
In normal cells, it assures the proper regulation of gene expression and stable gene …
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
K Polyak, RA Weinberg - Nature Reviews Cancer, 2009 - nature.com
Transitions between epithelial and mesenchymal states have crucial roles in embryonic
development. Emerging data suggest a role for these processes in regulating cellular …
development. Emerging data suggest a role for these processes in regulating cellular …
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
R Jaenisch, A Bird - Nature genetics, 2003 - nature.com
Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …
functionally heterogeneous owing to the differential expression of genes. Many of these …
Epigenetics in cancer
M Esteller - New England Journal of Medicine, 2008 - Mass Medical Soc
Gene transcription can be activated or inhibited by a reversible modification of the gene; this
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
[HTML][HTML] The epigenomics of cancer
Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …
Cancer epigenomics: DNA methylomes and histone-modification maps
M Esteller - Nature reviews genetics, 2007 - nature.com
An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …
on gene expression, we measured methylation, RNA polymerase occupancy and histone …