Current trends in pharmaceutical wet granulation have been shifted from traditional
approach to systematic and modern approaches, enabling the production of highly …

Seeded granulation is one of the recently adopted wet granulation techniques. The seeded
granules consist of high-density core nuclei and low-density particles layered on the outside …

This chapter describes the application of lactose as excipient in the pharmaceutical industry.
About 60%–70% of pharmaceutical dosage forms contain lactose, and in volume it is one of …

This paper presents a multi-compartment population balance model for wet granulation
coupled with DEM (discrete element method) simulations. Methodologies are developed to …

For emergency control of bleeding, there is a strong demand for topical hemostatic materials
that can not only stop bleeding rapidly but also be carried and used conveniently. The aim of …

Purpose of the research The purpose of the research was to investigate the effect of the
manufacturing process of the controlled release hydrophilic matrix tablets on their hydration …

High shear granulation of powders with a wide size distribution can lead to the formation of
core-shell particles consisting of a few larger particles in the core with a shell of fine …

Implementation of a Monte Carlo simulation for the solution of population balance equations
(PBEs) requires choice of initial sample number (N0), number of replicates (M), and number …

In this paper we present an experimental technique and a novel colourimetric image
analysis algorithm to economically evaluate particle residence times within regions of batch …

Purpose: To develop a method for the measurement of carbon dioxide (CO 2) released from
effervescent formulations. Methods: Effervescent granules were prepared using sodium …