This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

A specialized cubic-millimeter hotspot in the rostrodorsal quadrant of medial shell in nucleus
accumbens (NAc) of rats may mediate opioid enhancement of gustatory hedonic impact or …

With rising rates of obesity, research continues to explore the contributions of homeostatic
and hedonic mechanisms related to eating behaviour. In this Review, we synthesize the …

Highlights•What the new DSM-5 means for the concept of behavioral addiction.•Common
theoretical framework for substance addiction, behavioral addictions and OCD.•Pathological …

Neurochemical pathways involved in pathological overeating and obesity are poorly
understood. Although previous studies have shown increased μ-opioid receptor (MOR) and …

The mechanism of action of the combination therapy, naltrexone/bupropion (NB), for obesity
has not been fully described to date. Weight loss attempts rarely result in long-term success …

Music's universality and its ability to deeply affect emotions suggest an evolutionary origin.
Previous investigators have found that naltrexone (NTX), a μ-opioid antagonist, may induce …

Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical
and psychiatric conditions such as forms of obesity and eating disorders. Although feeding …

Food has both homeostatic and hedonic components, which makes it a potent natural
reward. Food related reward could therefore promote an escalation of intake and trigger …