The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to
protein carriers. Conjugation transformed the T cell-independent polysaccharide vaccines of …

Vaccine design and licensing depend on the choice of protective antigens and the
demonstration of their efficacy. Ideally efficacy correlates with some measurement of …

Methods: A total of 4707 influenza vaccine–naive healthy children 6 to 72 months old were
randomized in a ratio of 2: 2: 1 to receive 2 doses of MF-59–adjuvanted influenza vaccine …

Background. Influenza is a common and potentially serious infection in children. Although
there is interest in broadening the use of influenza vaccine in healthy children, there are few …

Background. Several disorders have been attributed to measles-mumps-rubella (MMR)
vaccination during the past decade. The aim of this prospective follow-up study was to …

After the introduction of effective Haemophilus influenzae type b (Hib) conjugate vaccines,
clinical practice has driven the development of combination vaccines comprising Hib …

Background. Viral upper respiratory infections (URIs) are considered major risk factors for
acute otitis media (AOM) in young children. We studied the epidemiology and relative roles …

The present rapid growth in the availability of safe and effective vaccines provides a
continuing need to expand and simplify vaccine administration programs. The replacement …

Background Advantages to combining childhood vaccines include reducing the number of
visits, injections and patient discomfort, increasing compliance and optimising prevention …

Study of the epidemiology of childhood infection reveals that the brunt of disease for a
number of invasive bacterial infections is borne by children under the age of 4 years …