Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg
ulcers, and pressure ulcers. They are a challenge to wound care professionals and …

Biologic therapies, including stem cells, platelet-rich plasma, growth factors, and other
biologically active adjuncts, have recently received increased attention in the basic science …

Abstract Purpose According to the World Health organization (WHO), more than 10% in
people older than 60 years suffer from osteoarthritis (OA). Over the last years, there has …

Background: The lack of a standardized system for describing cell therapies acts as a barrier
to advancement in clinical and basic research and practice. The aim of this study was to …

Mesenchymal stem—or stromal—cells (MSCs) have been administered in hundreds of
clinical trials for multiple indications, making them some of the most commonly used …

Background: Adult mesenchymal stem cells (MSCs) were first isolated from bone marrow by
Friedenstein in 1976. These cells were clonogenic, non-haematopoietic, and able to …

Mesenchymal stem or stromal cells (MSCs) are non-hematopoietic stem cells that facilitate
tissue regeneration through mechanisms involving self-renewal and differentiation …

Articular cartilage defects of the knee are common among athletes where the physical
demands of sport result in significant stresses on joints. Chondral defects are associated …

Hypoxia-inducible factor (HIF) signalling is intricately involved in coupling angiogenesis and
osteogenesis during bone development and repair. Activation of HIFs in response to a …

Atrophic non-union is attributed to biological failure of the fracture repair process. It occurs in
up to 10% of fractures, results in significant morbidity to patients and treatment often requires …