Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …

The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …

Abstract Background Dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD), which share many clinical, neurochemical, and morphological features, have been …

Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …

Abnormal aggregation of proteins into filamentous aggregates commonly associates with
many diseases, such as Alzheimer's disease, Parkinson's disease and type-2 diabetes …

Objective Mild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by
later life emergent neuropsychiatric symptoms (NPS) that represent an at-risk state for …

Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders
characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are …

We assessed the prevalence of common altered brain proteins in 296 cognitively
unimpaired subjects ranging from age 50 to 102 years. The incidence and the stage of …

Background: Dementia is a syndrome characterized by progressive cognitive impairment
that interferes with independent function in daily activities. Symptoms of dementia depend …

The current nosological concept of α-synucleinopathies characterized by the presence of
Lewy bodies (LBs) includes Parkinson's disease (PD), Parkinson's disease dementia (PDD) …