Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein
interactions. Understanding the role of the multiple structural and post-translational …

An unprecedented opportunity to integrate~ 100 years of meticulous in vitro biomolecular
research is currently provided in the light of recent advances in methods to visualize closer …

Cryo-EM of large, macromolecular assemblies has seen a significant increase in the
numbers of high-resolution structures since the arrival of direct electron detectors. However …

Cell death pathways such as apoptosis can be activated in response to oxidative stress,
enabling the disposal of damaged cells. In contrast, controlled intracellular redox events are …

Peroxiredoxins (PRDXs) are abundant peroxidases present in all kingdoms of life. Recently,
they have been shown to also carry out additional roles as molecular chaperones. To …

Peroxiredoxins are antioxidant proteins primarily responsible for detoxification of
hydroperoxides in cells. On exposure to various cellular stresses, peroxiredoxins can …

Reactive oxygen species (ROS) are key molecules regulating various cellular processes.
However, what the cellular targets of ROS are and how their functions are regulated is …

Significance: Decrypting the cellular response to oxidative stress relies on a comprehensive
understanding of the redox signaling pathways stimulated under oxidizing conditions …

The ability of proteins to form hierarchical structures through self-assembly provides an
opportunity to synthesize and organize nanoparticles. Ordered nanoparticle assemblies are …

The peroxiredoxins are a well characterised family of toroidal proteins which can self-
assemble into a striking array of quaternary structures, including protein nanotubes, making …