Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …

Multicomponent reactions (MCRs) are remarkable one-pot combinatorial synthetic tools
involving at least three reactants whose nearly all atoms are incorporated in the final …

The local treatment of inflammatory bowel disease (IBD) by enzyme therapeutics is
challenging owing to hostile environments in the gastrointestinal tract, leading to the …

Oral delivery of proteins has opened a new perspective for the treatment of different
diseases. However, advances of oral protein formulation are usually hindered by protein …

With the fast growth of protein therapeutics, efficient, precise, and universal delivery
platforms are highly required. However, very few reports have discussed the progress of …

Intracellular delivery of therapeutic biomacromolecules is often challenged by the poor
transmembrane and limited endosomal escape. Here, we establish a combinatorial library …

Isocyanide is an important class of active synthon with a special electronic structure and
abundant chemical properties, which can participate in various organic reactions and has a …

Carrier-mediated intracellular protein delivery holds tremendous application potential in
biology and medicine. The ideal carrier should be well-controlled and cost-effective and …

In recent years, intracellular delivery of protein drugs has attracted great attention, and
polymer-based systems have been extensively exploited to develop efficient and safe …

Much of current clinical interest has focused on mRNA therapeutics for the treatment of lung-
associated diseases, such as infections, genetic disorders, and cancers. However, the safe …