Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics
JJ Rennick, APR Johnston, RG Parton - Nature nanotechnology, 2021 - nature.com
Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
A Ciesielska, M Matyjek, K Kwiatkowska - Cellular and molecular life …, 2021 - Springer
Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …
Integrins as biomechanical sensors of the microenvironment
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
Every step of the way: integrins in cancer progression and metastasis
Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …
Integrins are the main cellular adhesion receptors that through multifaceted roles as …
Galectins at a glance
L Johannes, R Jacob, H Leffler - Journal of cell science, 2018 - journals.biologists.com
Galectins are carbohydrate-binding proteins that are involved in many physiological
functions, such as inflammation, immune responses, cell migration, autophagy and …
functions, such as inflammation, immune responses, cell migration, autophagy and …
Integrin trafficking in cells and tissues
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …
Geometry of a DNA Nanostructure Influences Its Endocytosis: Cellular Study on 2D, 3D, and in Vivo Systems
Fabrication of nanoscale DNA devices to generate 3D nano-objects with precise control of
shape, size, and presentation of ligands has shown tremendous potential for therapeutic …
shape, size, and presentation of ligands has shown tremendous potential for therapeutic …
RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …
investigated as therapeutic targets over the last decades, motivated by their multiple …
Galectin-3: one molecule for an alphabet of diseases, from A to Z
Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix
interactions, growth, proliferation, differentiation, and inflammation. It is not surprising …
interactions, growth, proliferation, differentiation, and inflammation. It is not surprising …
How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?
VT Cong, JL Houng, M Kavallaris, X Chen… - Chemical Society …, 2022 - pubs.rsc.org
Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs
into the diseased cells. However, there has been less focus on exploiting the differences in …
into the diseased cells. However, there has been less focus on exploiting the differences in …