Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Vitamin D and cardiovascular disease

PE Norman, JT Powell - Circulation research, 2014 - Am Heart Assoc
Vitamin D plays a classical hormonal role in skeletal health by regulating calcium and
phosphorus metabolism. Vitamin D metabolites also have physiological functions in …

Vitamin D and cardiovascular disease: controversy unresolved

I Al Mheid, AA Quyyumi - Journal of the American College of Cardiology, 2017 - jacc.org
Vitamin D deficiency is typically caused by inadequate cutaneous synthesis secondary to
decreased exposure to sunlight. Serum levels of 25-hydroxyvitamin D l< 20 ng/ml are …

Vitamin D: beyond bone

S Christakos, M Hewison, DG Gardner… - Annals of the New …, 2013 - Wiley Online Library
In recent years, vitamin D has been received increased attention due to the resurgence of
vitamin D deficiency and rickets in developed countries and the identification of extraskeletal …

A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging

PL Kuo, JA Schrack, MD Shardell… - Journal of Internal …, 2020 - Wiley Online Library
Over the past three decades, considerable effort has been dedicated to quantifying the pace
of ageing yet identifying the most essential metrics of ageing remains challenging due to …

Vitamin D and cardiovascular disease: is the evidence solid?

I Al Mheid, RS Patel, V Tangpricha… - European heart …, 2013 - academic.oup.com
Vitamin D deficiency, prevalent in 30–50% of adults in developed countries, is largely due to
inadequate cutaneous production that results from decreased exposure to sunlight, and to a …

Mendelian randomization studies do not support a role for vitamin D in coronary artery disease

D Manousaki, LE Mokry, S Ross… - Circulation …, 2016 - Am Heart Assoc
Background—Observational studies support a possible association between decreased
vitamin D levels and risk of coronary artery disease (CAD); however, it remains unclear …

Vitamin D status and hypertension: a review

L Ke, RS Mason, M Kariuki, E Mpofu… - … blood pressure control, 2015 - Taylor & Francis
Vitamin D is a steroid prohormone synthesized in the skin following ultraviolet exposure and
also achieved through supplemental or dietary intake. While there is strong evidence for its …

[HTML][HTML] The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes

OH Ryu, W Chung, S Lee, KS Hong… - The Korean journal of …, 2014 - ncbi.nlm.nih.gov
Methods We enrolled patients who were taking antidiabetic medications or managed their
diabetes using lifestyle changes. We excluded patients who were taking vitamin D or …

Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial

A Raed, J Bhagatwala, H Zhu, NK Pollock, SJ Parikh… - PLoS …, 2017 - journals.plos.org
Background Clinical trials are scant and equivocal on whether vitamin D can ameliorate
arterial stiffness, particularly in populations at high risk for vitamin D deficiency and …