Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
[HTML][HTML] ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
Vascular endothelial cells and innate immunity
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …
participate in both innate and adaptive immune responses. We previously reported that, in …
NLRP3 inflammasome in neurological diseases, from functions to therapies
L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …
Inhibition of the NLRP3/IL‐1β axis protects against sepsis‐induced cardiomyopathy
K Busch, M Kny, N Huang, TE Klassert… - Journal of cachexia …, 2021 - Wiley Online Library
Background Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical
data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome …
data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome …
Inflammasomes in the CNS
JG Walsh, DA Muruve, C Power - Nature Reviews Neuroscience, 2014 - nature.com
Microglia and macrophages in the CNS contain multimolecular complexes termed
inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as …
inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as …
Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens
LA Knodler, SM Crowley, HP Sham, H Yang… - Cell host & …, 2014 - cell.com
Inflammasome-mediated host defenses have been extensively studied in innate immune
cells. Whether inflammasomes function for innate defense in intestinal epithelial cells, which …
cells. Whether inflammasomes function for innate defense in intestinal epithelial cells, which …
Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers
There are multiple sources of reactive oxygen species (ROS) in the cell. As a major site of
ROS production, mitochondria have drawn considerable interest because it was recently …
ROS production, mitochondria have drawn considerable interest because it was recently …
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
E Mezzaroma, S Toldo, D Farkas… - Proceedings of the …, 2011 - National Acad Sciences
Acute myocardial infarction (AMI) initiates an intense inflammatory response that promotes
cardiac dysfunction, cell death, and ventricular remodeling. The molecular events underlying …
cardiac dysfunction, cell death, and ventricular remodeling. The molecular events underlying …
[HTML][HTML] Uric acid, hyperuricemia and vascular diseases
Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high
levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological …
levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological …