Pharmaceutical drug analysis (PDA), besides quantifying drugs and related substances
(RS), can enrich drug discovery (DD) by suggesting new leads. PDA may be extended …

Forced degradation studies have been used to simplify analytical methodology development
and achieve a deeper knowledge about the inherent stability of active pharmaceutical …

Panobinostat (PAN) is an inhibitor of histone deacetylase (HDAC) that has been granted
approval by the US Regulator for the purpose of treating chronic lymphocytic leukemia …

A stressed degradation (oxidation) was employed to produce metabolites from an active
pharmaceutical ingredient (API) with large molecular weight (about 900 g/mol). An analytical …

The present study focused upon the forced degradation behaviour of fosamprenavir (FPV),
an antiretroviral drug. A total of six degradation products (DPs) were separated on a non …

The drug substance, acalabrutinib was subjected to hydrolytic (acid, base and neutral) and
oxidative stress degradation as per ICH recommendations. Degradation products (DPs) …

Aliskiren was selected as a compound of potential concern among a suspect screening list
of more than 40,000 substances on a basis of high occurrence, potential risk and the …

In the pharmaceutical industry, forced degradation tests are used to assess the stability of
drug samples. Examining degradation products under stress is beneficial for determining …

Panobinostat (PAN) is an inhibitor of histone deacetylase (HDAC) that has been granted
approval by the US Regulator for the purpose of treating chronic lymphocytic leukemia …

Contaminants of emerging concern (CECs) are pointed as one of the main threats to the
water quality for the next decades. One of the main goals of this PhD thesis was focused on …