Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that
seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans …

Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Background The aging process is not univocal, both body and brain age. Neurological
disorders are a major cause of disability and death worldwide. According to the Global …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

During the last 20 years, numerous clinical trials have examined the therapeutic usefulness
of melatonin in different fields of medicine. The objective of this article is to review, in depth …

Melatonin is known to possess several properties of value for healthy aging, as a direct and
indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic …

Exogenous melatonin is used in a number of situations, first and foremost in the treatment of
sleep disorders and jet leg. However, the hypnotic, antinociceptive, and anticonvulsant …

One of the most common causes of mortality and morbidity in children is perinatal hypoxia-
ischemia (HI). In spite of the advances in neonatology, its incidence is not diminishing …

A large body of experimental and clinical evidence has strongly suggested that monoamines
play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and …