Background In recent years, we have accomplished a deeper understanding about the
pathophysiology of major depressive disorder (MDD). Nevertheless, this improved …

Objectives: The overview outlines two decades of research from the European Group for the
Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based …

Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …

A number of candidate gene studies focused on major depression (MD) and antidepressant
(AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a …

Background The type and quantities of antidepressants are increasing, but the efficacy and
safety of first-line and emerging drugs vary between studies. In this article, we estimated the …

In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

The primary objective of this review is to give an overview of the main findings of the
European multicenter project “Patterns of Treatment Resistance and Switching Strategies in …

Depression is a common and disabling psychiatric disorder with a complex etiology, which
includes predisposing risk genes and environmental stressors. Variation in the Catechol-O …

For over a decade, the European Group for the Study of Resistant Depression (GSRD) has
examined single nucleotide polymorphisms (SNP) and clinical parameters in regard to …

Major depressive disorder (MDD) is an emergent cause of personal and socio‐economic
burden, both for the high prevalence of the disorder and the unsatisfying response rate of …