Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
Chikungunya fever
K Bartholomeeusen, M Daniel, DA LaBeaud… - Nature Reviews …, 2023 - nature.com
Chikungunya virus is widespread throughout the tropics, where it causes recurrent
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …
Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …
ongoing research area that started before these versatile nanoparticles were successfully …
Emerging mRNA technologies: delivery strategies and biomedical applications
The great success achieved by the two highly-effective messenger RNA (mRNA) vaccines
during the COVID-19 pandemic highlights the great potential of mRNA technology. Through …
during the COVID-19 pandemic highlights the great potential of mRNA technology. Through …
A review on chikungunya virus epidemiology, pathogenesis and current vaccine development
TYV de Lima Cavalcanti, MR Pereira, SO de Paula… - Viruses, 2022 - mdpi.com
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in
many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile …
many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile …
Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d
N Chaudhary, LN Kasiewicz, AN Newby… - Nature Biomedical …, 2024 - nature.com
Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicle for RNA
therapeutics, partly because of established lipid structure–activity relationships focused on …
therapeutics, partly because of established lipid structure–activity relationships focused on …
The immunostimulatory nature of mRNA lipid nanoparticles
Abstract mRNA-Lipid nanoparticles (LNPs) are at the forefront of global medical research.
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …