[HTML][HTML] Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …
technologies have enabled the recapitulation of the major functions and architectures of …
Advances in TEER measurements of biological barriers in microphysiological systems
Biological barriers are multicellular structures that precisely regulate the transport of ions,
biomolecules, drugs, cells, and other organisms. Transendothelial/epithelial electrical …
biomolecules, drugs, cells, and other organisms. Transendothelial/epithelial electrical …
Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation
J Zhang, Z Chen, Y Zhang, X Wang, J Ouyang, J Zhu… - Lab on a Chip, 2021 - pubs.rsc.org
3D skin equivalents have been increasingly used in the pharmaceutical and cosmetic
industries, but the troublesome operation procedure and low throughput restricted their …
industries, but the troublesome operation procedure and low throughput restricted their …
[HTML][HTML] Recent trends of biomaterials and biosensors for organ-on-chip platforms
Abstract Organ-on-chip (OoC) platforms are a new class of advanced microfluidic devices
that have been attracting significant attention for drug development since they can allow a …
that have been attracting significant attention for drug development since they can allow a …
[HTML][HTML] In vitro microvascular engineering approaches and strategies for interstitial tissue integration
AR Murphy, MC Allenby - Acta Biomaterialia, 2023 - Elsevier
The increasing gap between clinical demand for tissue or organ transplants and the
availability of donated tissue highlights the emerging opportunities for lab-grown or …
availability of donated tissue highlights the emerging opportunities for lab-grown or …
Models for barrier understanding in health and disease in lab-on-a-chips
The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction
of these barriers can lead to various pathological processes, including increased exposure …
of these barriers can lead to various pathological processes, including increased exposure …
[HTML][HTML] Advances in the engineering of the outer blood-retina barrier: From in-vitro modelling to cellular therapy
C Dujardin, W Habeler, C Monville, D Letourneur… - Bioactive Materials, 2024 - Elsevier
The outer blood-retina barrier (oBRB), crucial for the survival and the proper functioning of
the overlying retinal layers, is disrupted in numerous diseases affecting the retina, leading to …
the overlying retinal layers, is disrupted in numerous diseases affecting the retina, leading to …
[HTML][HTML] Integrating mechanical sensor readouts into organ-on-a-chip platforms
IA Morales, CM Boghdady, BE Campbell… - … in Bioengineering and …, 2022 - frontiersin.org
Organs-on-a-chip have emerged as next-generation tissue engineered models to accurately
capture realistic human tissue behaviour, thereby addressing many of the challenges …
capture realistic human tissue behaviour, thereby addressing many of the challenges …
Combining ultrasound-mediated intracellular delivery with microfluidics in various applications
G Huang, L Lin, S Wu, H Dang, X Cheng, Y Liu, H You - BioChip Journal, 2024 - Springer
Ultrasound-mediated intracellular delivery is one of the popular technologies based on
membrane rupture at present. To date, ultrasound directly acts on a large number of cells to …
membrane rupture at present. To date, ultrasound directly acts on a large number of cells to …
[HTML][HTML] Mimicking blood and lymphatic vasculatures using microfluidic systems
The role of the circulatory system, containing the blood and lymphatic vasculatures, within
the body, has become increasingly focused on by researchers as dysfunction of either of the …
the body, has become increasingly focused on by researchers as dysfunction of either of the …