Inhaled Pulmonary Vasodilators for the Treatment of Right Ventricular Failure in Cardio-Thoracic Surgery: Is One Better than the Others?

M Benedetto, G Piccone, L Gottin, A Castelli… - Journal of Clinical …, 2024 - mdpi.com
Right ventricular failure (RFV) is a potential complication following cardio-thoracic surgery,
with an incidence ranging from 0.1% to 30%. The increase in pulmonary vascular resistance …

Efficacy of treprostinil in the SU5416‐hypoxia model of severe pulmonary arterial hypertension: haemodynamic benefits are not associated with improvements in …

KR Chaudhary, Y Deng, CM Suen… - British journal of …, 2018 - Wiley Online Library
Background and Purpose Pulmonary arterial hypertension (PAH) is a life‐threatening
disease that leads to progressive pulmonary hypertension, right heart failure and death …

Effects of inhaled iloprost on lung mechanics and myocardial function during one-lung ventilation in chronic obstructive pulmonary disease patients combined with …

N Kim, SH Lee, Y Joe, T Kim, H Shin… - Anesthesia & …, 2020 - journals.lww.com
BACKGROUND: The ventilation/perfusion mismatch in chronic obstructive pulmonary
disease (COPD) patients can exacerbate cardiac function as well as pulmonary …

Acute iloprost inhalation improves right ventricle function in pulmonary artery hypertension: a cardiac magnetic resonance study

JH Li, HD Zhang, ZZ Wang, QQ Lu, D Li… - Frontiers in …, 2019 - frontiersin.org
Background: Right ventricle (RV) function is among the most important prognostic factors for
pulmonary arterial hypertension (PAH) patients. Inhaled iloprost, an inhaled member of the …

Inotropic effects of prostacyclins on the right ventricle are abolished in isolated rat hearts with right-ventricular hypertrophy and failure

S Holmboe, A Andersen, J Johnsen… - Journal of …, 2017 - journals.lww.com
Background: Prostacyclin mimetics are vasodilatory agents used in the treatment of
pulmonary arterial hypertension. The direct effects of prostanoids on right-ventricular (RV) …

Effects of chronic treprostinil treatment on experimental right heart hypertrophy and failure

S Axelgaard, S Holmboe, S Ringgaard… - Cardiology in the …, 2017 - cambridge.org
BackgroundRight heart function is an important predictor of morbidity and mortality in
pulmonary arterial hypertension and many CHD. We investigated whether treatment with the …

Prostacyclins have no direct inotropic effect on isolated atrial strips from the normal and pressure-overloaded human right heart

S Holmboe, A Andersen, RV Jensen… - Pulmonary …, 2017 - journals.sagepub.com
Prostacyclins are vasodilatory agents used in the treatment of pulmonary arterial
hypertension. The direct effects of prostacyclins on right heart function are still not clarified …

Pulmonary hypertension in fibrosing idiopathic interstitial pneumonia: Uncertainties, challenges and opportunities

RE Girgis, MM Hoeper - The Journal of Heart and Lung Transplantation, 2021 - Elsevier
Pulmonary hypertension is a serious complication of chronic fibrosing idiopathic interstitial
pneumonia (PH-fIIP) leading to greater morbidity and mortality. The pathophysiologic basis …

Nasally inhaled nitric oxide for sudden right-sided heart failure in the intensive care unit: no time like the present

K Ghadimi, S Rajagopal - Journal of cardiothoracic and …, 2018 - pmc.ncbi.nlm.nih.gov
Inhaled nitric oxide (iNO) is an exogenously administered pulmonary vasodilator (iPVD),
which serves to replicate the actions of endogenously derived vascular endothelial nitric …

Novel therapeutic strategies for the treatment of pulmonary arterial hypertension

C Suen - 2017 - ruor.uottawa.ca
Pulmonary arterial hypertension (PAH) is a progressive disease that results in increased
pulmonary vasculature resistance, causing right ventricular (RV) remodeling, which …