Neuroprotective effect of antioxidants in the brain
KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release
S Mahmoud, M Gharagozloo, C Simard, D Gris - Cells, 2019 - mdpi.com
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …
the central nervous system (CNS); however, residual glutamate in the extracellular space is …
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …
guidelines for the definition and interpretation of cell death from morphological, biochemical …
[HTML][HTML] 13 reasons why the brain is susceptible to oxidative stress
The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …
[HTML][HTML] Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases
A Armada-Moreira, JI Gomes, CC Pina… - Frontiers in cellular …, 2020 - frontiersin.org
Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …
[HTML][HTML] Nitric oxide regulates plant responses to drought, salinity, and heavy metal stress
Plants are exposed to diverse abiotic stresses like drought, heat, salinity, and high-metal
concentrations at different stages of their life cycle. As protection against stress, plants …
concentrations at different stages of their life cycle. As protection against stress, plants …
Combination drug therapy for the management of Alzheimer's disease
MT Kabir, MS Uddin, AA Mamun, P Jeandet… - International Journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Even though the
number of AD patients is rapidly growing, there is no effective treatment for this …
number of AD patients is rapidly growing, there is no effective treatment for this …
Targeting NMDA receptors in stroke: new hope in neuroprotection
QJ Wu, M Tymianski - Molecular brain, 2018 - Springer
Abstract NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …
[HTML][HTML] The dual role of iNOS in cancer
Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous
free radical whose predominant functions is that of a messenger through cGMP. In …
free radical whose predominant functions is that of a messenger through cGMP. In …
[HTML][HTML] Excitotoxicity and stroke: identifying novel targets for neuroprotection
Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …