Neuroprotective effect of antioxidants in the brain

KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release

S Mahmoud, M Gharagozloo, C Simard, D Gris - Cells, 2019 - mdpi.com
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

[HTML][HTML] 13 reasons why the brain is susceptible to oxidative stress

JN Cobley, ML Fiorello, DM Bailey - Redox biology, 2018 - Elsevier
The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …

[HTML][HTML] Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases

A Armada-Moreira, JI Gomes, CC Pina… - Frontiers in cellular …, 2020 - frontiersin.org
Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

[HTML][HTML] Nitric oxide regulates plant responses to drought, salinity, and heavy metal stress

RBS Nabi, R Tayade, A Hussain, KP Kulkarni… - Environmental and …, 2019 - Elsevier
Plants are exposed to diverse abiotic stresses like drought, heat, salinity, and high-metal
concentrations at different stages of their life cycle. As protection against stress, plants …

Combination drug therapy for the management of Alzheimer's disease

MT Kabir, MS Uddin, AA Mamun, P Jeandet… - International Journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Even though the
number of AD patients is rapidly growing, there is no effective treatment for this …

Targeting NMDA receptors in stroke: new hope in neuroprotection

QJ Wu, M Tymianski - Molecular brain, 2018 - Springer
Abstract NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …

[HTML][HTML] The dual role of iNOS in cancer

F Vannini, K Kashfi, N Nath - Redox biology, 2015 - Elsevier
Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous
free radical whose predominant functions is that of a messenger through cGMP. In …

[HTML][HTML] Excitotoxicity and stroke: identifying novel targets for neuroprotection

TW Lai, S Zhang, YT Wang - Progress in neurobiology, 2014 - Elsevier
Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …