The increasing incidence of microbial resistance and newly emerging pathogens have
become a serious challenge for public health. More and more efforts have been directed to …

Viruses have been recognized as the etiological agents responsible for many pathological
conditions ranging from asymptomatic infections to serious diseases, even leading to death …

Novel tetrazole-based diselenides and selenoquinones were synthesized via azido-Ugi and
sequential nucleophilic substitution (SN) strategy. Molecular docking study into mammalian …

Herein we report the synthesis of peptide-like and tetrazole-based organoselenium
compounds via Ugi and Ugi-azide reactions, respectively. The organoselenium compounds' …

Recently, a new generation of highly promising inhibitors bearing β-keto-enol functionality
has emerged. Reported herein is the first synthesis and use of novel designed drugs based …

Recently, photoclick chemistry emerged as a powerful tool employed in several research
fields, from medicinal chemistry and biology to material sciences. The growing interest in this …

A new family of promising inhibitors bearing β-keto–enol functionality with greatly improved
pharmacophore properties has been prepared. Herein, a series of novel derivatives of β …

The novel coronavirus that caused COVID-19 pandemic is SARS-CoV-2. Although various
vaccines are currently being used to prevent the disease's severe consequences, there is …

In this study, we report new classes of potent tyrosinase inhibitors identified by enhanced
structure-based virtual screening prediction; the enzyme and melanin content assays were …

A series of flavonoid-triazolyl hybrids were synthesized and evaluated as novel inhibitors of
hepatitis C virus (HCV). The results of anti-HCV activity assays showed that most of the …