Abstract The Bromo-and Extra-Terminal domain (BET) family proteins act as “readers” of
acetylated histones and they are important transcription regulators. BRD2, BRD3, BRD4 and …

Despite dramatic advances in cancer research and therapy, breast cancer remains a tricky
health problem and represents a top biomedical research priority. Nowadays, breast cancer …

Glioblastoma (GBM) is a central nervous system tumor with poor prognosis due to the rapid
development of resistance to mono chemotherapy and poor brain targeted delivery …

A subset of stem-like cells in glioblastoma (GBM; GSC) underlies tumor propagation,
therapeutic resistance, and tumor recurrence. Immune evasion is critical for GSCs to carry …

Maintaining the balance between eliciting immune responses against foreign proteins and
tolerating self-proteins is crucial for maintenance of homeostasis. The functions of …

Despite the development of new targeted and immune therapies, the prognosis of metastatic
melanoma remains bleak. Therefore, it is critical to better understand the mechanisms …

Abstract Programmed death-ligand 1 (PD-L1) expression on the surface of tumour cells can
cause tumour immune evasion. Benefits of combining anti-PD-L1 therapy with nab …

Carbon nanotubes (CNTs), as advanced nanotechnology with specific properties and
structures, have presented practical drug delivery properties. Ginsenoside Rg3 is a …

Acetylation of NF-κB's RelA subunit at lysine-310 (AcLys310) helps to maintain constitutive
NF-κB activity in cancers such as triple-negative breast cancer (TNBC). Bromodomain …

Highlights•Short digest on the latest updates regarding immunotherapy with a focus on PD-
L1.•Summary of the recent advances in the field of small molecule PD-L1 …