Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

Recent single-cell studies of cancer in both mice and humans have identified the
emergence of a myofibroblast population specifically marked by the highly restricted leucine …

Therapeutic cancer vaccines are designed to increase tumor-specific T cell immunity.
However, suppressive mechanisms within the tumor microenvironment (TME) may limit T …

T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …

Immune checkpoint inhibitor (ICI) therapy can induce complete responses in mismatch
repair-deficient and microsatellite instability-high (d-MMR/MSI-H) colorectal cancers (CRCs) …

Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but
whether this determines protective versus ineffective anti-cancer immunity is poorly …

Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …

Tissue-resident macrophages adapt to local signals within tissues to acquire specific
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …

Abstract γδ T cells are important tissue-resident, innate T cells that are critical for tissue
homeostasis. γδ cells are associated with positive prognosis in most tumors; however, little …