Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics
The importance of drug dosing time in pharmacokinetics, pharmacodynamics, and toxicity is
receiving increasing attention from the scientific community. In spite of mounting evidence …
receiving increasing attention from the scientific community. In spite of mounting evidence …
Key factors in effective patient-tailored dosing of fluoroquinolones in urological infections: Interindividual pharmacokinetic and pharmacodynamic variability
O Estradé, V Vozmediano, N Carral, A Isla, M González… - Antibiotics, 2022 - mdpi.com
Fluoroquinolones (FQs) are a critical group of antimicrobials prescribed in urological
infections as they have a broad antimicrobial spectrum of activity and a favorable tissue …
infections as they have a broad antimicrobial spectrum of activity and a favorable tissue …
Population pharmacokinetic model and limited sampling strategies for personalized dosing of levofloxacin in tuberculosis patients
SHJ van den Elsen, MGG Sturkenboom… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic
variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve …
variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve …
Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models
J Cortés-Ríos, RC Hermida… - PLOS Computational …, 2022 - journals.plos.org
Blood pressure (BP) follows a circadian variation, increasing during active hours, showing a
small postprandial valley and a deeper decrease during sleep. Nighttime reduction of 10 …
small postprandial valley and a deeper decrease during sleep. Nighttime reduction of 10 …
Levofloxacin‐induced QTc prolongation depends on the time of drug administration
L Kervezee, V Gotta, J Stevens… - CPT …, 2016 - Wiley Online Library
Understanding the factors influencing a drug's potential to prolong the QTc interval on an
electrocardiogram is essential for the correct evaluation of its safety profile. To explore the …
electrocardiogram is essential for the correct evaluation of its safety profile. To explore the …
Influence of renal function and age on the pharmacokinetics of levofloxacin in patients with bone and joint infections
G Eloy, D Lebeaux, M Launay… - Antibiotics, 2020 - mdpi.com
Despite its efficacy and toxicity being exposure-related, levofloxacin pharmacokinetics in
patients with bone and joint infections has been poorly described to date, so the possible …
patients with bone and joint infections has been poorly described to date, so the possible …
Effects of diurnal variation and food on gastrointestinal transit of 111In-labeled hydrogel matrix extended-release tablets and 99mTc-labeled pellets in humans
A Kambayashi, K Sako, H Kondo - Journal of Pharmaceutical Sciences, 2020 - Elsevier
The aim of this research was to characterize the effect of food ingestion and circadian rhythm
on the gastrointestinal transit of 2 dosage forms: a hydrogel matrix extended-release (ER) …
on the gastrointestinal transit of 2 dosage forms: a hydrogel matrix extended-release (ER) …
[PDF][PDF] Некоторые клинико-фармакологические аспекты терапии внебольничной пневмонии
ДВ Цыганко, НГ БЕРДНИКОВА, ЛМ Красных… - Эффективная …, 2019 - umedp.ru
Лекции для врачей Page 1 28 Эффективная фармакотерапия. 27/2019 - . . , . . , . . ., . . , . . ,
. . , . . : , berdnad@mail.ru : . ., . ., . . . - // . 2019. . 15. 27. . 28–36. DOI 10.33978/2307-3586-2019-15-27-28-36 …
. . , . . : , berdnad@mail.ru : . ., . ., . . . - // . 2019. . 15. 27. . 28–36. DOI 10.33978/2307-3586-2019-15-27-28-36 …
Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients
L Zhang, P Hu - Clinical interventions in aging, 2017 - Taylor & Francis
Aim Pharmacoeconomic cost-effectiveness analysis of two different dosage regimens of
levofloxacin in the treatment of acute lower respiratory tract infection in elderly patients …
levofloxacin in the treatment of acute lower respiratory tract infection in elderly patients …
Role of pharmacokinetics in chronotherapeutics
D Lu, Y Wang, M Chen, H Zhao, D Dong - Circadian Pharmacokinetics, 2020 - Springer
Life on Earth is dictated by circadian changes (eg, sunlight, temperature, and humidity) in
the environment caused by the planet's rotation around its own axis. All forms of life have …
the environment caused by the planet's rotation around its own axis. All forms of life have …