Metformin (MTF) occupies a major and fundamental position in the therapeutic management
of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF …

Diabetes mellitus is a chronic disease, typified by hyperglycemia resulting from failures in
complex multifactorial metabolic functions, that requires life-long medication. Prolonged …

Objectives: Describe the mechanism of action of sulfonylureas. Explain the potential adverse
effects of sulfonylureas. Review sulfonylurea overdoses and the treatment options available …

Growing clinical evidence shows that sulfonylurea therapy for patients with type 2 diabetic
mellitus (T2DM) contributes to progressive worsening of their liver. The present study …

Oxidative stress and aberrant insulin signaling transduction play vital roles in type 2
diabetes mellitus (T2DM). Our previous research has demonstrated that trilobatin (TLB) …

Inhibition of α-glucosidase activity is an important strategy in lowering the concentration of
blood sugar. In this paper, using domestic and foreign characteristic food-derived …

Accumulating evidences strongly support the correlations between the compositions of gut
microbiome and therapeutic effects on Type 2 diabetes (T2D). Notably, gut microbes such as …

We found compound 12N-p-trifluoromethylbenzenesulfonyl matrinane (1) was a potent anti-
diabetic agent. Thirty-five tricyclic matrinic derivatives were synthesized and determined for …

Somatostatin is a peptide that plays a variety of roles such as neurotransmitter and
endocrine regulator; its actions as a cell regulator in various tissues of the human body are …

Background Since the twenty-first century, the prevalence of diabetes has risen globally year
by year. In Gansu Province, an economically underdeveloped province in northwest China …