Genome folding through loop extrusion by SMC complexes

IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

Genome control by SMC complexes

C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion

S Luo, J Zhang, AJB Kreutzberger, A Eaton… - Science …, 2022 - science.org
SARS-CoV-2 Omicron subvariants have generated a worldwide health crisis due to
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …

New insights into genome folding by loop extrusion from inducible degron technologies

E de Wit, EP Nora - Nature Reviews Genetics, 2023 - nature.com
Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

The role of chromatin loop extrusion in antibody diversification

Y Zhang, X Zhang, HQ Dai, H Hu, FW Alt - Nature Reviews Immunology, 2022 - nature.com
Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …

Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization

J Zagelbaum, A Schooley, J Zhao… - Nature Structural & …, 2023 - nature.com
Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …

Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries

LH Chang, S Ghosh, A Papale, JM Luppino… - Nature …, 2023 - nature.com
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …

A walk through the SMC cycle: From catching DNAs to shaping the genome

R Oldenkamp, BD Rowland - Molecular cell, 2022 - cell.com
SMC protein complexes are molecular machines that provide structure to chromosomes.
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …

Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops

S Liu, Y Cao, K Cui, Q Tang, K Zhao - Nature communications, 2022 - nature.com
The three-dimensional genomic structure plays a critical role in gene expression, cellular
differentiation, and pathological conditions. It is pivotal to elucidate fine-scale chromatin …

Cohesin regulates homology search during recombinational DNA repair

A Piazza, H Bordelet, A Dumont, A Thierry… - Nature cell …, 2021 - nature.com
Homologous recombination repairs DNA double-strand breaks (DSB) using an intact dsDNA
molecule as a template. It entails a homology search step, carried out along a conserved …