Genome folding through loop extrusion by SMC complexes
IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …
serve important structural and regulatory roles. It has been proposed that these genomic …
Genome control by SMC complexes
C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion
SARS-CoV-2 Omicron subvariants have generated a worldwide health crisis due to
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …
New insights into genome folding by loop extrusion from inducible degron technologies
Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …
wire distant loci together for gene regulation. These loops are continuously created …
The role of chromatin loop extrusion in antibody diversification
Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …
between convergently oriented CTCF-binding elements. Recent studies indicate that …
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
A walk through the SMC cycle: From catching DNAs to shaping the genome
R Oldenkamp, BD Rowland - Molecular cell, 2022 - cell.com
SMC protein complexes are molecular machines that provide structure to chromosomes.
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops
The three-dimensional genomic structure plays a critical role in gene expression, cellular
differentiation, and pathological conditions. It is pivotal to elucidate fine-scale chromatin …
differentiation, and pathological conditions. It is pivotal to elucidate fine-scale chromatin …
Cohesin regulates homology search during recombinational DNA repair
Homologous recombination repairs DNA double-strand breaks (DSB) using an intact dsDNA
molecule as a template. It entails a homology search step, carried out along a conserved …
molecule as a template. It entails a homology search step, carried out along a conserved …