Breast cancer in the era of integrating “Omics” approaches

C Rossi, I Cicalini, MC Cufaro, A Consalvo… - Oncogenesis, 2022 - nature.com
Worldwide, breast cancer is the leading cause of cancer-related deaths in women. Breast
cancer is a heterogeneous disease characterized by different clinical outcomes in terms of …

SWATH‐MS as a tool for biomarker discovery: From basic research to clinical applications

SI Anjo, C Santa, B Manadas - Proteomics, 2017 - Wiley Online Library
In the era of quantitative proteomics, where mass spectrometry plays a pivotal role, in
particular associated with the use of data‐independent acquisition, it is time to perform an …

High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS

Z Wang, M Mülleder, I Batruch, A Chelur… - Elife, 2022 - elifesciences.org
The possibility to record proteomes in high throughput and at high quality has opened new
avenues for biomedical research, drug discovery, systems biology, and clinical translation …

Omics-based investigations of breast cancer

AN Neagu, D Whitham, P Bruno, H Morrissiey… - Molecules, 2023 - mdpi.com
Breast cancer (BC) is characterized by an extensive genotypic and phenotypic
heterogeneity. In-depth investigations into the molecular bases of BC phenotypes …

Proteomics biomarkers for solid tumors: Current status and future prospects

I Belczacka, A Latosinska, J Metzger… - Mass spectrometry …, 2019 - Wiley Online Library
Cancer is a heterogeneous multifactorial disease, which continues to be one of the main
causes of death worldwide. Despite the extensive efforts for establishing accurate diagnostic …

Proteomics-based identification of dysregulated proteins in breast cancer

AN Neagu, M Jayathirtha, D Whitham, P Mutsengi… - Proteomes, 2022 - mdpi.com
Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …

Comprehensive analysis of individual variation in the urinary proteome revealed significant gender differences*[S]

C Shao, M Zhao, X Chen, H Sun, Y Yang, X Xiao… - Molecular & Cellular …, 2019 - ASBMB
Disease biomarkers are the measurable changes associated with a pathophysiological
process. Without homeostatic control, urine accumulates systematic changes in the body …

A sensitive electrochemical aptasensing platform based on exonuclease recycling amplification and host-guest recognition for detection of breast cancer biomarker …

S Yang, M You, F Zhang, Q Wang, P He - Sensors and Actuators B …, 2018 - Elsevier
In this study, a novel and sensitive electrochemical aptasensing platform was fabricated for
the detection of the breast cancer biomarker HER2. HER2 aptamer was firstly hybridized …

[HTML][HTML] Proteomics and its applications in breast cancer

AN Neagu, D Whitham, E Buonanno… - American journal of …, 2021 - ncbi.nlm.nih.gov
Breast cancer is an individually unique, multi-faceted and chameleonic disease, an eternal
challenge for the new era of high-integrated precision diagnostic and personalized …

Urinary biomarkers in prostate cancer detection and monitoring progression

D Wu, J Ni, J Beretov, P Cozzi, M Willcox… - Critical reviews in …, 2017 - Elsevier
Prostate cancer (CaP) is the most common cancer in men and the second leading cause of
cancer deaths in males in Australia. Although serum prostate-specific antigen (PSA) has …