Translation inhibition and stress granules in the antiviral immune response
C McCormick, DA Khaperskyy - Nature Reviews Immunology, 2017 - nature.com
Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …
rapidly reprioritize the translation machinery in response to varied environmental assaults …
Mechanistic insights into mammalian stress granule dynamics
The accumulation of stalled translation preinitiation complexes (PICs) mediates the
condensation of stress granules (SGs). Interactions between prion-related domains and …
condensation of stress granules (SGs). Interactions between prion-related domains and …
[HTML][HTML] Distinct stages in stress granule assembly and disassembly
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when
translation initiation is limited and contain a biphasic structure with stable core structures …
translation initiation is limited and contain a biphasic structure with stable core structures …
[HTML][HTML] Stressful steps: progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules
H Glauninger, CJW Hickernell, JAM Bard… - Molecular cell, 2022 - cell.com
Stress-induced condensation of mRNA and protein into massive cytosolic clusters is
conserved across eukaryotes. Known as stress granules when visible by imaging, these …
conserved across eukaryotes. Known as stress granules when visible by imaging, these …
[HTML][HTML] Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease
H Mahboubi, U Stochaj - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Stress granule (SG) assembly is a conserved cellular strategy to minimize stress-related
damage and promote cell survival. Beyond their fundamental role in the stress response …
damage and promote cell survival. Beyond their fundamental role in the stress response …
mRNP granules: assembly, function, and connections with disease
JR Buchan - RNA biology, 2014 - Taylor & Francis
Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …
[HTML][HTML] Eukaryotic stress granules: the ins and outs of translation
The stress response in eukaryotic cells often inhibits translation initiation and leads to the
formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress …
formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress …
[HTML][HTML] Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD
MY Fang, S Markmiller, AQ Vu, A Javaherian… - Neuron, 2019 - cell.com
Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative
diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To …
diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To …
RNA granules: post-transcriptional and epigenetic modulators of gene expression
P Anderson, N Kedersha - Nature reviews Molecular cell biology, 2009 - nature.com
The composition of cytoplasmic messenger ribonucleoproteins (mRNPs) is determined by
their nuclear and cytoplasmic histories and reflects past functions and future fates. The …
their nuclear and cytoplasmic histories and reflects past functions and future fates. The …
[HTML][HTML] Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
Background Cell-derived microvesicles (MVs) have been described as a new mechanism of
cell-to-cell communication. MVs after internalization within target cells may deliver genetic …
cell-to-cell communication. MVs after internalization within target cells may deliver genetic …