Translation inhibition and stress granules in the antiviral immune response

C McCormick, DA Khaperskyy - Nature Reviews Immunology, 2017 - nature.com
Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …

Mechanistic insights into mammalian stress granule dynamics

MD Panas, P Ivanov, P Anderson - Journal of Cell Biology, 2016 - rupress.org
The accumulation of stalled translation preinitiation complexes (PICs) mediates the
condensation of stress granules (SGs). Interactions between prion-related domains and …

[HTML][HTML] Distinct stages in stress granule assembly and disassembly

JR Wheeler, T Matheny, S Jain, R Abrisch, R Parker - elife, 2016 - elifesciences.org
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when
translation initiation is limited and contain a biphasic structure with stable core structures …

[HTML][HTML] Stressful steps: progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules

H Glauninger, CJW Hickernell, JAM Bard… - Molecular cell, 2022 - cell.com
Stress-induced condensation of mRNA and protein into massive cytosolic clusters is
conserved across eukaryotes. Known as stress granules when visible by imaging, these …

[HTML][HTML] Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease

H Mahboubi, U Stochaj - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Stress granule (SG) assembly is a conserved cellular strategy to minimize stress-related
damage and promote cell survival. Beyond their fundamental role in the stress response …

mRNP granules: assembly, function, and connections with disease

JR Buchan - RNA biology, 2014 - Taylor & Francis
Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …

[HTML][HTML] Eukaryotic stress granules: the ins and outs of translation

JR Buchan, R Parker - Molecular cell, 2009 - cell.com
The stress response in eukaryotic cells often inhibits translation initiation and leads to the
formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress …

[HTML][HTML] Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD

MY Fang, S Markmiller, AQ Vu, A Javaherian… - Neuron, 2019 - cell.com
Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative
diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To …

RNA granules: post-transcriptional and epigenetic modulators of gene expression

P Anderson, N Kedersha - Nature reviews Molecular cell biology, 2009 - nature.com
The composition of cytoplasmic messenger ribonucleoproteins (mRNPs) is determined by
their nuclear and cytoplasmic histories and reflects past functions and future fates. The …

[HTML][HTML] Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs

F Collino, MC Deregibus, S Bruno, L Sterpone… - PloS one, 2010 - journals.plos.org
Background Cell-derived microvesicles (MVs) have been described as a new mechanism of
cell-to-cell communication. MVs after internalization within target cells may deliver genetic …