Leydig cells: formation, function, and regulation
BR Zirkin, V Papadopoulos - Biology of reproduction, 2018 - academic.oup.com
Herein we summarize important discoveries made over many years about Leydig cell
function and regulation. Fetal Leydig cells produce the high levels of androgen (testosterone …
function and regulation. Fetal Leydig cells produce the high levels of androgen (testosterone …
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
PC White, PW Speiser - Endocrine reviews, 2000 - academic.oup.com
More than 90% of cases of congenital adrenal hyperplasia (CAH, the inherited inability to
synthesize cortisol) are caused by 21-hydroxylase deficiency. Females with severe, classic …
synthesize cortisol) are caused by 21-hydroxylase deficiency. Females with severe, classic …
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
Steroid hormones regulate diverse physiological functions such as reproduction, blood salt
balance, maintenance of secondary sexual characteristics, response to stress, neuronal …
balance, maintenance of secondary sexual characteristics, response to stress, neuronal …
Androgen Levels Increase by Intratumoral De novo Steroidogenesis during Progression of Castration-Resistant Prostate Cancer
JA Locke, ES Guns, AA Lubik, HH Adomat, SC Hendy… - Cancer research, 2008 - AACR
Although systemic androgen deprivation prolongs life in advanced prostate cancer,
remissions are temporary because patients almost uniformly progress to a state of a …
remissions are temporary because patients almost uniformly progress to a state of a …
StAR protein and the regulation of steroid hormone biosynthesis
DM Stocco - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract Steroid hormone biosynthesis is acutely regulated by pituitary trophic hormones
and other steroidogenic stimuli. This regulation requires the synthesis of a protein whose …
and other steroidogenic stimuli. This regulation requires the synthesis of a protein whose …
Epigenetics of endometriosis
SW Guo - Molecular human reproduction, 2009 - academic.oup.com
Endometriosis is a common gynecologic disorder with an enigmatic etiopathogenesis.
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …
Structure and lipid transport mechanism of a StAR-related domain
Y Tsujishita, JH Hurley - Nature structural biology, 2000 - nature.com
The steroidogenic acute regulatory protein (StAR) regulates acute steroidogenesis in the
adrenal cortex and gonads by promoting the translocation of cholesterol to the mitochondrial …
adrenal cortex and gonads by promoting the translocation of cholesterol to the mitochondrial …
Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds
HM Scott, JI Mason, RM Sharpe - Endocrine reviews, 2009 - academic.oup.com
Masculinization depends on adequate production of testosterone by the fetal testis within a
specific “masculinization programming window.” Disorders resulting from subtle deficiencies …
specific “masculinization programming window.” Disorders resulting from subtle deficiencies …
Cell biology of Leydig cells in the testis
SG Haider - Int Rev Cytol, 2004 - books.google.com
This article reviews results on diVerentiation, structure, and regulation of Leydig cells in the
testes of rodents and men. Two different populations—fetal and adult Leydig cells—can be …
testes of rodents and men. Two different populations—fetal and adult Leydig cells—can be …
Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression.
LP Walsh, C McCormick, C Martin… - Environmental health …, 2000 - ehp.niehs.nih.gov
Recent reports demonstrate that many currently used pesticides have the capacity to disrupt
reproductive function in animals. Although this reproductive dysfunction is typically …
reproductive function in animals. Although this reproductive dysfunction is typically …