[HTML][HTML] Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents

NAG Dos Santos, RS Ferreira… - Food and chemical …, 2020 - Elsevier
Cisplatin has dramatically improved the survival rate of cancer patients, but it has also
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …

Cardiovascular effects of caffeic acid and its derivatives: a comprehensive review

H Silva, NMF Lopes - Frontiers in physiology, 2020 - frontiersin.org
Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic
acids with an interesting array of biological activities; eg, antioxidant, anti-inflammatory …

Caffeic acid phenethyl ester and therapeutic potentials

G Murtaza, S Karim, MR Akram… - BioMed Research …, 2014 - Wiley Online Library
Caffeic acid phenethyl ester (CAPE) is a bioactive compound of propolis extract. The
literature search elaborates that CAPE possesses antimicrobial, antioxidant, anti …

Effects of polyphenols on oxidative stress, inflammation, and interconnected pathways during spinal cord injury

S Fakhri, F Abbaszadeh, SZ Moradi… - Oxidative medicine …, 2022 - Wiley Online Library
Despite the progression in targeting the complex pathophysiological mechanisms of
neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective …

Caffeic acid, a versatile pharmacophore: an overview

M Touaibia, J Jean-Francois… - Mini reviews in medicinal …, 2011 - benthamdirect.com
The caffeic acid scaffold, which is abundant in nature, is extremely versatile and is found in a
number of biologically active molecules. The purpose of this review is to provide an …

[HTML][HTML] Promising influences of caffeic acid and caffeic acid phenethyl ester against natural and chemical toxins: A comprehensive and mechanistic review

S Ehtiati, M Alizadeh, F Farhadi, K Khalatbari… - Journal of Functional …, 2023 - Elsevier
Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) are natural compounds that have
been found in various foods and plants. These compounds have attracted much attention in …

Bioactivity and chemical synthesis of caffeic acid phenethyl ester and its derivatives

P Zhang, Y Tang, NG Li, Y Zhu, JA Duan - Molecules, 2014 - mdpi.com
Caffeic acid phenethyl ester (CAPE), as one of the main active ingredients of the natural
product propolis, shows the unique biological activities such as anti-tumor, anti-oxidation …

Cytoprotective effects of natural compounds against oxidative stress

J Mehta, S Rayalam, X Wang - Antioxidants, 2018 - mdpi.com
Oxidative stress, an imbalance between reactive oxygen species and antioxidants, has been
witnessed in pathophysiological states of many disorders. Compounds identified from …

Nrf2-mediated HO-1 induction coupled with the ERK signaling pathway contributes to indirect antioxidant capacity of caffeic acid phenethyl ester in HepG2 cells

JK Kim, HD Jang - International journal of molecular sciences, 2014 - mdpi.com
The objective of this study is to investigate the contributing effect of the nuclear transcription
factor-erythroid 2-related factor 2 (Nrf2)-mediated signaling pathway on the indirect …

Antiaging Mechanism of natural compounds: Effects on autophagy and oxidative stress

E Taylor, Y Kim, K Zhang, L Chau, BC Nguyen… - Molecules, 2022 - mdpi.com
Aging is a natural biological process that manifests as the progressive loss of function in
cells, tissues, and organs. Because mechanisms that are meant to promote cellular longevity …